The 2017 Foundation for Arthroplasty Research and Education (FARE) grant recipient, Thorsten M. Seyler, MD, PhD of Duke University, is conducting a prospective, randomized study, “Perioperative Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty.” This study is aiming to establish level I evidence for single-dose versus 24-hour antibiotic prophylaxis in primary total knee arthroplasty (TKA) and is based on the most recent release of the Centers for Medicare & Medicaid Service’s guideline for perioperative antibiotics, which is based on limited evidence.

This study requires 90-day follow-up, and data is collected through a web-based portal. Duke University can act as the central IRB for interested sites as needed. If you are interested in collaborating to help generate data to establish a standard for perioperative antibiotics in TKA, please contact Chiara Rodgers, Research Manager at